Chronic alveolar haemorrhage in a paediatric patient: a diagnostic and treatment challenge.
Identifieur interne : 000E96 ( Main/Exploration ); précédent : 000E95; suivant : 000E97Chronic alveolar haemorrhage in a paediatric patient: a diagnostic and treatment challenge.
Auteurs : Ana Freitas [Portugal] ; Virgílio Senra [Portugal] ; Ant Nio Marinho [Portugal] ; Margarida Guedes [Portugal]Source :
- BMJ case reports [ 1757-790X ] ; 2015.
Descripteurs français
- KwdFr :
- Adolescent, Anticorps anticytoplasme des polynucléaires neutrophiles (analyse), Azathioprine (usage thérapeutique), Biopsie, Cyclophosphamide (usage thérapeutique), Femelle, Hormones corticosurrénaliennes (usage thérapeutique), Humains, Hydroxychloroquine (usage thérapeutique), Hémoptysie (anatomopathologie), Hémoptysie (étiologie), Hémorragie (diagnostic), Hémorragie (traitement médicamenteux), Hémorragie (étiologie), Hémosidérose (anatomopathologie), Hémosidérose (traitement médicamenteux), Maladies pulmonaires (anatomopathologie), Maladies pulmonaires (traitement médicamenteux), Myeloperoxidase (métabolisme), Rituximab (administration et posologie), Rituximab (usage thérapeutique), Vascularite (diagnostic), Vascularite (traitement médicamenteux), Vascularite (étiologie).
- MESH :
- administration et posologie : Rituximab.
- analyse : Anticorps anticytoplasme des polynucléaires neutrophiles.
- anatomopathologie : Hémoptysie, Hémosidérose, Maladies pulmonaires.
- diagnostic : Hémorragie, Vascularite.
- métabolisme : Myeloperoxidase.
- traitement médicamenteux : Hémorragie, Hémosidérose, Maladies pulmonaires, Vascularite.
- usage thérapeutique : Azathioprine, Cyclophosphamide, Hormones corticosurrénaliennes, Hydroxychloroquine, Rituximab.
- étiologie : Hémoptysie, Hémorragie, Vascularite.
- Adolescent, Biopsie, Femelle, Humains.
English descriptors
- KwdEn :
- Adolescent, Adrenal Cortex Hormones (therapeutic use), Antibodies, Antineutrophil Cytoplasmic (analysis), Azathioprine (therapeutic use), Biopsy, Cyclophosphamide (therapeutic use), Female, Hemoptysis (etiology), Hemoptysis (pathology), Hemorrhage (diagnosis), Hemorrhage (drug therapy), Hemorrhage (etiology), Hemosiderosis (drug therapy), Hemosiderosis (pathology), Humans, Hydroxychloroquine (therapeutic use), Lung Diseases (drug therapy), Lung Diseases (pathology), Peroxidase (metabolism), Rituximab (administration & dosage), Rituximab (therapeutic use), Vasculitis (diagnosis), Vasculitis (drug therapy), Vasculitis (etiology).
- MESH :
- chemical , administration & dosage : Rituximab.
- chemical , analysis : Antibodies, Antineutrophil Cytoplasmic.
- chemical , metabolism : Peroxidase.
- chemical , therapeutic use : Adrenal Cortex Hormones, Azathioprine, Cyclophosphamide, Hydroxychloroquine, Rituximab.
- diagnosis : Hemorrhage, Vasculitis.
- drug therapy : Hemorrhage, Hemosiderosis, Lung Diseases, Vasculitis.
- etiology : Hemoptysis, Hemorrhage, Vasculitis.
- pathology : Hemoptysis, Hemosiderosis, Lung Diseases.
- Adolescent, Biopsy, Female, Humans.
Abstract
Pulmonary haemosiderosis is characterised by chronic alveolar haemorrhage, which can lead to serious cardiorespiratory complications. Although considered idiopathic in most patients, there are many possible aetiologies. We present a case of an 18-year-old woman with pulmonary haemosiderosis since 4 years of age, with an inconclusive initial study, who was treated with systemic corticosteroids and hydroxychloroquine until the age of 12 years, and azathioprine since then. Multiple exacerbations led to interstitial lung disease with restrictive functional pattern. Unilateral cochlear deafness was diagnosed at the age of 12 years and occasional polyarthralgias were recorded. When she was 16 years of age the study revealed an atypical myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) pattern. Cyclophosphamide and rituximab were administered with resolution of respiratory insufficiency and functional disability, without new episodes of alveolar haemorrhage. This case of chronic pulmonary haemorrhage was revealed to be an ANCA vasculitis, the diagnosis of which was possible only after 12 years of symptoms, with clinical and functional improvement with the association of cyclophosphamide and rituximab.
DOI: 10.1136/bcr-2014-206856
PubMed: 25899510
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000258
- to stream PubMed, to step Curation: 000258
- to stream PubMed, to step Checkpoint: 000249
- to stream Ncbi, to step Merge: 000287
- to stream Ncbi, to step Curation: 000287
- to stream Ncbi, to step Checkpoint: 000287
- to stream Main, to step Merge: 000E97
- to stream Main, to step Curation: 000E96
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chronic alveolar haemorrhage in a paediatric patient: a diagnostic and treatment challenge.</title>
<author><name sortKey="Freitas, Ana" sort="Freitas, Ana" uniqKey="Freitas A" first="Ana" last="Freitas">Ana Freitas</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Centro Hospitalar do Porto, Porto, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Department of Pediatrics, Centro Hospitalar do Porto, Porto</wicri:regionArea>
<wicri:noRegion>Porto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Senra, Virgilio" sort="Senra, Virgilio" uniqKey="Senra V" first="Virgílio" last="Senra">Virgílio Senra</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Centro Hospitalar do Porto, Porto, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Department of Pediatrics, Centro Hospitalar do Porto, Porto</wicri:regionArea>
<wicri:noRegion>Porto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marinho, Ant Nio" sort="Marinho, Ant Nio" uniqKey="Marinho A" first="Ant Nio" last="Marinho">Ant Nio Marinho</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Centro Hospitalar do Porto, Porto, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Department of Medicine, Centro Hospitalar do Porto, Porto</wicri:regionArea>
<wicri:noRegion>Porto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guedes, Margarida" sort="Guedes, Margarida" uniqKey="Guedes M" first="Margarida" last="Guedes">Margarida Guedes</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Centro Hospitalar do Porto, Porto, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Department of Pediatrics, Centro Hospitalar do Porto, Porto</wicri:regionArea>
<wicri:noRegion>Porto</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:25899510</idno>
<idno type="pmid">25899510</idno>
<idno type="doi">10.1136/bcr-2014-206856</idno>
<idno type="wicri:Area/PubMed/Corpus">000258</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000258</idno>
<idno type="wicri:Area/PubMed/Curation">000258</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000258</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000249</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000249</idno>
<idno type="wicri:Area/Ncbi/Merge">000287</idno>
<idno type="wicri:Area/Ncbi/Curation">000287</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000287</idno>
<idno type="wicri:Area/Main/Merge">000E97</idno>
<idno type="wicri:Area/Main/Curation">000E96</idno>
<idno type="wicri:Area/Main/Exploration">000E96</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Chronic alveolar haemorrhage in a paediatric patient: a diagnostic and treatment challenge.</title>
<author><name sortKey="Freitas, Ana" sort="Freitas, Ana" uniqKey="Freitas A" first="Ana" last="Freitas">Ana Freitas</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Centro Hospitalar do Porto, Porto, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Department of Pediatrics, Centro Hospitalar do Porto, Porto</wicri:regionArea>
<wicri:noRegion>Porto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Senra, Virgilio" sort="Senra, Virgilio" uniqKey="Senra V" first="Virgílio" last="Senra">Virgílio Senra</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Centro Hospitalar do Porto, Porto, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Department of Pediatrics, Centro Hospitalar do Porto, Porto</wicri:regionArea>
<wicri:noRegion>Porto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marinho, Ant Nio" sort="Marinho, Ant Nio" uniqKey="Marinho A" first="Ant Nio" last="Marinho">Ant Nio Marinho</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Centro Hospitalar do Porto, Porto, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Department of Medicine, Centro Hospitalar do Porto, Porto</wicri:regionArea>
<wicri:noRegion>Porto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guedes, Margarida" sort="Guedes, Margarida" uniqKey="Guedes M" first="Margarida" last="Guedes">Margarida Guedes</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Centro Hospitalar do Porto, Porto, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Department of Pediatrics, Centro Hospitalar do Porto, Porto</wicri:regionArea>
<wicri:noRegion>Porto</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">BMJ case reports</title>
<idno type="eISSN">1757-790X</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adrenal Cortex Hormones (therapeutic use)</term>
<term>Antibodies, Antineutrophil Cytoplasmic (analysis)</term>
<term>Azathioprine (therapeutic use)</term>
<term>Biopsy</term>
<term>Cyclophosphamide (therapeutic use)</term>
<term>Female</term>
<term>Hemoptysis (etiology)</term>
<term>Hemoptysis (pathology)</term>
<term>Hemorrhage (diagnosis)</term>
<term>Hemorrhage (drug therapy)</term>
<term>Hemorrhage (etiology)</term>
<term>Hemosiderosis (drug therapy)</term>
<term>Hemosiderosis (pathology)</term>
<term>Humans</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Lung Diseases (drug therapy)</term>
<term>Lung Diseases (pathology)</term>
<term>Peroxidase (metabolism)</term>
<term>Rituximab (administration & dosage)</term>
<term>Rituximab (therapeutic use)</term>
<term>Vasculitis (diagnosis)</term>
<term>Vasculitis (drug therapy)</term>
<term>Vasculitis (etiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Anticorps anticytoplasme des polynucléaires neutrophiles (analyse)</term>
<term>Azathioprine (usage thérapeutique)</term>
<term>Biopsie</term>
<term>Cyclophosphamide (usage thérapeutique)</term>
<term>Femelle</term>
<term>Hormones corticosurrénaliennes (usage thérapeutique)</term>
<term>Humains</term>
<term>Hydroxychloroquine (usage thérapeutique)</term>
<term>Hémoptysie (anatomopathologie)</term>
<term>Hémoptysie (étiologie)</term>
<term>Hémorragie (diagnostic)</term>
<term>Hémorragie (traitement médicamenteux)</term>
<term>Hémorragie (étiologie)</term>
<term>Hémosidérose (anatomopathologie)</term>
<term>Hémosidérose (traitement médicamenteux)</term>
<term>Maladies pulmonaires (anatomopathologie)</term>
<term>Maladies pulmonaires (traitement médicamenteux)</term>
<term>Myeloperoxidase (métabolisme)</term>
<term>Rituximab (administration et posologie)</term>
<term>Rituximab (usage thérapeutique)</term>
<term>Vascularite (diagnostic)</term>
<term>Vascularite (traitement médicamenteux)</term>
<term>Vascularite (étiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Rituximab</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Antineutrophil Cytoplasmic</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peroxidase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenal Cortex Hormones</term>
<term>Azathioprine</term>
<term>Cyclophosphamide</term>
<term>Hydroxychloroquine</term>
<term>Rituximab</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Rituximab</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps anticytoplasme des polynucléaires neutrophiles</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Hémoptysie</term>
<term>Hémosidérose</term>
<term>Maladies pulmonaires</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hemorrhage</term>
<term>Vasculitis</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Hémorragie</term>
<term>Vascularite</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hemorrhage</term>
<term>Hemosiderosis</term>
<term>Lung Diseases</term>
<term>Vasculitis</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hemoptysis</term>
<term>Hemorrhage</term>
<term>Vasculitis</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Myeloperoxidase</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Hemoptysis</term>
<term>Hemosiderosis</term>
<term>Lung Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hémorragie</term>
<term>Hémosidérose</term>
<term>Maladies pulmonaires</term>
<term>Vascularite</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Azathioprine</term>
<term>Cyclophosphamide</term>
<term>Hormones corticosurrénaliennes</term>
<term>Hydroxychloroquine</term>
<term>Rituximab</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hémoptysie</term>
<term>Hémorragie</term>
<term>Vascularite</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Biopsy</term>
<term>Female</term>
<term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Biopsie</term>
<term>Femelle</term>
<term>Humains</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Pulmonary haemosiderosis is characterised by chronic alveolar haemorrhage, which can lead to serious cardiorespiratory complications. Although considered idiopathic in most patients, there are many possible aetiologies. We present a case of an 18-year-old woman with pulmonary haemosiderosis since 4 years of age, with an inconclusive initial study, who was treated with systemic corticosteroids and hydroxychloroquine until the age of 12 years, and azathioprine since then. Multiple exacerbations led to interstitial lung disease with restrictive functional pattern. Unilateral cochlear deafness was diagnosed at the age of 12 years and occasional polyarthralgias were recorded. When she was 16 years of age the study revealed an atypical myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) pattern. Cyclophosphamide and rituximab were administered with resolution of respiratory insufficiency and functional disability, without new episodes of alveolar haemorrhage. This case of chronic pulmonary haemorrhage was revealed to be an ANCA vasculitis, the diagnosis of which was possible only after 12 years of symptoms, with clinical and functional improvement with the association of cyclophosphamide and rituximab.</div>
</front>
</TEI>
<affiliations><list><country><li>Portugal</li>
</country>
</list>
<tree><country name="Portugal"><noRegion><name sortKey="Freitas, Ana" sort="Freitas, Ana" uniqKey="Freitas A" first="Ana" last="Freitas">Ana Freitas</name>
</noRegion>
<name sortKey="Guedes, Margarida" sort="Guedes, Margarida" uniqKey="Guedes M" first="Margarida" last="Guedes">Margarida Guedes</name>
<name sortKey="Marinho, Ant Nio" sort="Marinho, Ant Nio" uniqKey="Marinho A" first="Ant Nio" last="Marinho">Ant Nio Marinho</name>
<name sortKey="Senra, Virgilio" sort="Senra, Virgilio" uniqKey="Senra V" first="Virgílio" last="Senra">Virgílio Senra</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E96 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000E96 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:25899510 |texte= Chronic alveolar haemorrhage in a paediatric patient: a diagnostic and treatment challenge. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25899510" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
This area was generated with Dilib version V0.6.33. |